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What is Ozempic®?

Ozempic® (semaglutide) injection for Type 2 Diabetes

Ozempic® is a brand name for the medication semaglutide, which is a type of glucagon-like peptide-1 receptor agonist (GLP-1 RA). It is used to treat type 2 diabetes in adults. Semaglutide works by mimicking the action of the hormone GLP-1, which helps regulate blood sugar levels by stimulating insulin release, slowing down gastric emptying, and reducing appetite.

Ozempic® is typically administered as a once-weekly injection under the skin (subcutaneous injection). It is often prescribed as part of a comprehensive treatment plan that includes diet, exercise, and other medications to improve glycemic control in people with type 2 diabetes.

In addition to lowering blood sugar levels, Ozempic® may also lead to weight loss for some individuals. It has been shown to be effective in reducing both HbA1c levels (a measure of average blood sugar levels over time) and body weight.

As with any medication, it’s important to use Ozempic® exactly as prescribed by your healthcare provider and to follow their instructions regarding dosage and administration. Be sure to discuss any potential side effects or concerns with your doctor to ensure that Ozempic® is the right treatment option for you.

Important Safety Information

Do not share your Ozempic® pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

The most important information to know about Ozempic® (semaglutide) includes:

  1. Risk of Hypoglycemia: Ozempic® can lower blood sugar levels, leading to hypoglycemia (low blood sugar). This can be potentially dangerous and may cause symptoms such as sweating, shakiness, fast heartbeat, dizziness, hunger, blurred vision, and tingling hands/feet. It’s crucial to monitor your blood sugar levels regularly, especially when starting treatment or changing the dose of Ozempic®.

  2. Pancreatitis Risk: Serious side effects, including pancreatitis (inflammation of the pancreas), have been reported with the use of Ozempic®. Inform your healthcare provider immediately if you experience persistent severe abdominal pain, which may radiate to the back and may worsen after eating.

  3. Thyroid Tumors and Cancer Risk: Ozempic® has been associated with an increased risk of thyroid tumors, including thyroid cancer. It’s important to undergo regular monitoring of thyroid function and to report any symptoms such as swelling or a lump in the neck, hoarseness, trouble swallowing, or shortness of breath to your healthcare provider.

  4. Acute Kidney Injury: Cases of acute kidney injury, sometimes requiring dialysis, have been reported with the use of Ozempic®. Inform your healthcare provider if you experience signs and symptoms of kidney problems, such as changes in urine output, swelling in the ankles or legs, or unexplained weight gain.

  5. Allergic Reactions: Serious allergic reactions, including anaphylaxis, may occur with the use of Ozempic®. Seek immediate medical attention if you experience symptoms such as swelling of the face, lips, tongue, or throat; difficulty breathing; or severe itching or rash.

  6. Injection Site Reactions: Like with any injectable medication, there is a risk of injection site reactions, such as redness, itching, or swelling. Rotate injection sites and follow proper injection techniques to minimize this risk.

It’s essential to discuss these risks and any other concerns with your healthcare provider before starting treatment with Ozempic®. Additionally, follow your healthcare provider’s instructions carefully regarding dosing, monitoring, and management of any potential side effects.

Do not use Ozempic® if:

  • you or any of your family have ever had MTC or if you have MEN 2.
  • you are allergic to semaglutide or any of the ingredients in Ozempic®. See symptoms of serious allergic reaction in “What are the possible side effects of Ozempic®?”.

Before using Ozempic®, tell your health care provider if you have any other medical conditions, including if you:

  • have or have had problems with your pancreas or kidneys. 
  • have a history of diabetic retinopathy.
  • are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Ozempic® will harm your unborn baby or passes into your breast milk. You should stop using Ozempic® 2 months before you plan to become pregnant.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and other medicines to treat diabetes, including insulin or sulfonylureas.

What are the possible side effects of Ozempic®?

Common side effects of Ozempic® (semaglutide) may include:

  1. Nausea: Feeling sick to your stomach or experiencing an urge to vomit.

  2. Diarrhea: Frequent bowel movements that are loose or watery.

  3. Vomiting: Forcefully expelling the contents of the stomach through the mouth.

  4. Abdominal Pain: Discomfort or cramping in the stomach area.

  5. Constipation: Difficulty passing stools or infrequent bowel movements.

  6. Headache: Aching or pressure in the head, often accompanied by sensitivity to light or sound.

  7. Decreased Appetite: A reduced desire to eat, which may lead to weight loss.

  8. Fatigue: Feeling tired or lacking energy.

  9. Dizziness: Feeling lightheaded or unsteady.

  10. Hypoglycemia: Low blood sugar levels, which can cause symptoms such as sweating, shakiness, fast heartbeat, dizziness, hunger, blurred vision, and tingling hands/feet.

Less common but more severe side effects of Ozempic® may include:

  1. Pancreatitis: Inflammation of the pancreas, which can cause severe abdominal pain.

  2. Thyroid Tumors and Cancer: As mentioned earlier, Ozempic® may increase the risk of thyroid tumors, including thyroid cancer.

  3. Acute Kidney Injury: Sudden loss of kidney function, which can lead to symptoms such as changes in urine output, swelling in the ankles or legs, or unexplained weight gain.

  4. Allergic Reactions: Serious allergic reactions, including anaphylaxis, may occur. Seek immediate medical attention if you experience symptoms such as swelling of the face, lips, tongue, or throat; difficulty breathing; or severe itching or rash.

It’s essential to report any side effects to your healthcare provider promptly, especially if they persist or worsen over time. Your healthcare provider can offer guidance on managing side effects and determine if any adjustments to your treatment plan are necessary.

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